Mirtha Dermisache was born in Buenos Aires in 1940. She studied visual arts at the Manuel Belgrano and Prilidiano Pueyrredón National Schools of Fine Arts, respectively.
In 1967 she finished her first 500-page book, afterwards continuing with the development of her graphisms, which continues to this day. Her works were published between 1970 and 1978 by the Center for Art and Communication, led by Jorge Glusberg.
In the 70s her graphisms were published by Marc Dachy and Guy Schraenen in Antwerp and were also published in the magazines Flash art, Doc(k)s, Kontext, Ephemera and Ax. Additionally, Ulises Carrión exhibited her works in the gallery Other books and so (Amsterdam), and Roberto Altmann did the same in the Malmö Konsthall (Sweden). During this same time, she created the Workshop of Creative Actions in Buenos Aires.
Starting in 2004 and together with Florent Fajole, she carried out a series of publishing devices that explore the dimensions of the installation and the printing process, highlighting different conceptual aspects of publications in the same spatial reality.
Her first solo show in Buenos Aires was in the gallery The Edge. Later, she exhibited her work at the MACBA (Barcelona) and the Center Pompidou (Paris).